Research

Cannabidiol is rapidly gaining attention as the key to the medicinal value of the cannabis plant. We have compiled links to the most relevant published research articles. This page will continue to be modified as new research is developed.

Recently Published

Jacobson & Porter
Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy

Dr. Margaret Gedde
Whole cannabis extract of high concentration cannabidiol may calm seizures in highly refractory pediatric epilepsies

NYU Langone Medical Center
Cannabidiol Conference 2013
Cannabidiols: Potential Uses in Epilepsy and Other Neurological Disorders

CBD for Epilepsy

Carlini EAMechoulam RLander N. “Anticonvulsant activity of four oxygenated Cannabidiol derivatives.” Research Communications in Chemical Pathology and Pharmacology. 1975 Sep;12(1):1-15.
http://www.ncbi.nlm.nih.gov/pubmed/1188178

Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats.J Pharmacol Exp Ther. 1977 Apr;201(1):26-32.
http://www.ncbi.nlm.nih.gov/pubmed/850145

Cunha et al. “Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients.sup.1. Pharmacology. 1980 21:175-185.
http://web.acsalaska.net/~warmgun/es201.html

Consroe PMartin ASingh V. “Antiepileptic potential of cannabidiol analogs.” Journal of Clinical Pharmacology. 1981 Aug-Sep;21(8-9 Suppl):428S-436S.
http://www.ncbi.nlm.nih.gov/pubmed/7298873

Karler RTurkanis SA. “The cannabinoids as potential antiepileptics.” Journal of Clinical Pharmacology. 1981 Aug-Sep;21(8-9 Suppl):437S-448S.
http://www.ncbi.nlm.nih.gov/pubmed/6975285

Carlini EACunha JM. “ Hypnotic and antiepileptic effects of cannabidiol.” Journal of Clinical Pharmacology. 1981 Aug-Sep;21(8-9 Suppl):417S-427S.
http://www.ncbi.nlm.nih.gov/pubmed/7028792

Consroe PBenedito MALeite JRCarlini EAMechoulam R. “ Effects of cannabidiol on behavioral seizures caused by convulsant drugs or current in mice.” European Journal of Pharmacology. 1982 Sep 24;83(3-4):293-8.
http://www.ncbi.nlm.nih.gov/pubmed/6129147

Lorenz R. “ On the application of cannabis in paediatrics and epileptology.” Neuro Endocrinology Letters. 2004 Feb-Apr;25(1-2):40-4
http://www.ncbi.nlm.nih.gov/pubmed/15159680

Alger Bradley E., Ph.D. ” Endocannabinoids and Their Implications for Epilepsy.” Epilepsy Currents. 2004 September; 4(5): 169–173.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176361

Wallace Robyn, Ph.D.  “ Cannabinoids: Defending the Epileptic Brain.” Epilepsy Currents. 2004 May; 4(3): 93–95
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176332

Smith PF. “ Cannabinoids as potential anti-epileptic drugs.” Current Opinion in Investigational Drugs. 2005 Jul;6(7):680-5
http://www.ncbi.nlm.nih.gov/pubmed/16044663

Monory Krisztina, Massa Federico, […], and Lutz Beat. “The Endocannabinoid System Controls Key Epileptogenic Circuits in the Hippocampus.” Neuron. 2006 August 17; 51(4): 455–466.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769341

Laxmikant S. DeshpandeSompong SombatiBlair Robert E. Carter Dawn S.,  Martin Billy R., and DeLorenzo Robert J.. ” Development of pharmacoresistance to benzodiazepines but not cannabinoids in the hippocampal neuronal culture model of status epilepticus.” Experimental Neurology. 2007 April; 204(2): 705–713.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2094113

Laxmikant S. DeshpandeBlair Robert E. Ziobro, Julie M., Sombati Sompong, Martin Billy R., and DeLorenzo Robert J.. ” Endocannabinoids block status epilepticus in cultured hippocampal neurons.” European Journal of Pharmacology 2007 March 8; 558(1-3): 52–59.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2617750

Jones Nicholas A.Hill Andrew J.Smith ImogenBevan Sarah A.Williams Claire M.Whalley Benjamin J., and Stephens Gary J.“Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo.” Journal of Pharmacology and Experimental Therapeutics. 2010 February; 332(2): 569–577.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2819831

Bhaskaran Muthu D.1,2 and Smith Bret N.1,2. “Cannabinoid-Mediated Inhibition of Recurrent Excitatory Circuitry in the Dentate Gyrus in a Mouse Model of Temporal Lobe Epilepsy.” PLoS One. 2010; 5(5): e10683.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2871782

Jones NAGlyn SEAkiyama SHill TDHill AJWeston SEBurnett MDYamasaki YStephens GJWhalley BJWilliams CM. “ Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.” Seizure. 2012 Jun;21(5):344-52.
http://www.ncbi.nlm.nih.gov/pubmed/22520455

Hofmann MEFrazier CJ. “ Marijuana, endocannabinoids, and epilepsy: potential and challenges for improved therapeutic intervention.” Experimental Neurology. 2013 Jun;244:43-50.
http://www.ncbi.nlm.nih.gov/pubmed/22178327

Fernández-Ruiz JSagredo OPazos MRGarcía CPertwee RMechoulam RMartínez-Orgado J. “ Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?” British Journal of Clinical Pharmacology. 2013 Feb;75(2):323-33.
http://www.ncbi.nlm.nih.gov/pubmed/22625422

Porter BE, Jacobson C. “Report of a Parent Survey of Cannabidiol-Enriched Cannabis Use in Pediatric Treatment-Resistant Epilepsy.” Epilepsy & Behavior (2013) http://dx.doi.org/10.1016/j.yebeh.2013.08.037

Other Research

Cannabinoid Chart

CBD for Schizophrenia

http://www.ncbi.nlm.nih.gov/pubmed/23109356 – 2013 Jan;5(1):46-51. doi: 10.1002/dta.1425. Epub 2012 Oct 25. Medical use of cannabis. Cannabidiol: a new light for schizophrenia?Deiana S. Source Department CNS Diseases Research, Boehringer Ingelheim Pharma GmbH & Co. K., Biberach an der Riss, Germany. serena.deiana@boehringer-ingelheim.com

CBD for Cancer

Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Mulitarget Effect. Solinas MMassi PCinquina VValenti MBolognini DGariboldi MMonti ERubino TParolaro DSource: Department of Theoretical and Applied Sciences, Biomedical Research Division, Centre of Neuroscience, University of Insubria, Busto Arsizio, Varese, Italy.
http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4

CBD for Nausea

Br J Pharmacol. 2011 Aug;163(7):1411-22. doi: 10.1111/j.1476-5381.2010.01176.x. Regulation of nausea and vomiting by cannabinoids. Parker LARock EMLimebeer CLSource: Department of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, Ontario, N1G 2W1, Canada. DA-9789

CBD for Alzheimer’s

Mol Pharmacol. 2011 Jun;79(6):964-73. doi: 10.1124/mol.111.071290. Epub 2011 Feb 24. Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease. Martín-Moreno AMReigada DRamírez BGMechoulam RInnamorato NCuadrado Ade Ceballos MLSource: Neurodegeneration Group, Department of Cellular, Molecular and Developmental Neurobiology, Instituto Cajal, CSIC, Madrid, Spain.

CBD for Parkinson’s

Brain Res. 2007 Feb 23;1134(1):162-70. Epub 2006 Dec 28. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease: importance of antioxidant and cannabinoid receptor-independent propertiesGarcía-Arencibia MGonzález Sde Lago ERamos JAMechoulam RFernández-Ruiz JSource: Departamento de Bioquímica y Biología Molecular III, Facultad de Medicina, Universidad Complutense, 28040-Madrid, Spain.